Depending on your audience ... a LOT.
LGBTQIA+ rights, women's rights and autonomy, economic disparities, racial prejudice, environmental destruction, politics in general, military aggression, police brutality, hate crimes, sexual assault. OMG the list goes on forever.
I think the only point I want to make is this: don't shy away from subjects just because some readers may take issue with it! Go ahead and disturb the comfortable, and let other readers know you see them and support them.